Health,Stem Cells, and Technology

Saturday, June 4, 2016

Colloidal Silver: Inhaled silver particles end up in the brain


Airborne silver nanoparticles that are common in occupational settings travel from the nose to the brain, where they can remain for weeks and trigger an immune response linked with injury, UC Davis researchers studying adult rats have found.

Author of the study, Dr Kent Pinkerton, Ph.D. at UC Davis, published in the journal Environmental Health Perspectives, urge greater attention to the health effects of silver nanoparticle exposure, given the increasing likelihood of exposure and how little is known about the risks to the central nervous system.

His team exposed adult male rats to a single dose of aerosolized silver nanoparticles measuring 20 or 110 nanometers (or one billionth of a meter) in diameter. The team used levels similar to what a human would receive after one day of light work in an occupation, such as manufacturing, where the nanoparticles would be present.

After evaluating the animals over the course of eight weeks, they found that particles of both sizes migrated through olfactory epithelial nerves into an area of the forebrain called the olfactory bulb.

While it was not much of a surprise that the 20nm particles reached the olfactory bulb, the 110nm particles were a different story. It should be physically impossible for this size to move through the olfactory epithelial nerves.

Almost immediately after being exposed to the nanoparticles, especially smaller ones, the team saw an activation of microglial cells in the brain. Microglial cells are a type of macrophage and are associated with free radical generation, indicating the possibility of central nervous system damage when activated.

Something to consider is the widespread use of colloidal silver, a suspension of silver nanoparticles.

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