Health,Stem Cells, and Technology

Sunday, June 26, 2011

BioRegenerative Sciences, Inc. Releases Stem Cell-Based, Anti-Aging Cosmeceuticals at A4M Congress -

BioRegenerative Sciences, Inc. Releases Stem Cell-Based, Anti-Aging Cosmeceuticals at A4M Congress -

Supporting Dig US Out: Learning To Buy USA Made Products

I've talked about and published a number of articles regarding the US economy and some of the steps needed to institute short- and long-term growth, for example, see my articles "Saving the US Economy: Effective Involvement of Government, Academia, and Industry," and "Choosing the Academic-Industrial-Government Complex or The End of Influence."

For a short- and long-term strategy and something we can all participate in immediately, try buying products that are made here at the USA. To this end, kudos to Jamie Norwood of Oakdale, CA for starting the new organization and website called "Dig U.S. Out." Jamie's new website is a means for consumers to learn about products that are made in the USA. Thank you Jamie...great idea and great implementation...for ideas alone are not enough!

And, FYI, all of the products sold by my company, BioRegenerative Sciences, Inc., are made in the USA.

Friday, June 24, 2011

Publicly Accessible Database Of Human DNA Sequence May Be Corrupted

Movement of genes in a “cut and paste” or a “copy and paste” manner within the genome of a single cell was first described in 1929 by Nobel Laureate, Dr. Barbara McClintock at Cold Spring Harbor Laboratories in Long Island, NY. Later, in 1951, V.J. Freeman demonstrated that genes can move from one organism to another without being the offspring of that organism, which is known as horizontal gene transfer (HGT).  Horizontal gene transfer between highly divergent species, in this case from human to bacterium, has now been described by Andersen and Seifert (2011).Those of us working in molecular biology know well the ease with which DNA preparations can be contaminated, and therefore great care is taught and used to prevent such contamination. Despite this, Longo and O’Neil (2011) report significant contamination of the publically accessible genome databases. Others, including the National Center for Biotechnology Information (NCBI), claim that the contamination of databases is not as widespread as reported in the Longo and O’Neil paper. NCBI states that most of the examples provided by the authors were of preliminary data submitted to the archives under rapid data release policies. Database users must understand that preliminary data are just that, preliminary, because they have not been screened and vetted the way finished data have.

Now, Langdon and Arno report significant in silico HGT  such that the human genome sequence database contains DNA sequences very like those of mycoplasma molds. According to Langdon and Arno the moulds infect not only molecular Biology laboratories, but were picked up by experimenters from contaminated samples and inserted into GenBank as if they were human. Further, at least one mouldy EST (Expressed Sequence Tag) has transferred from public databases to commercial tools (Affymetrix HG-U133 plus 2.0 microarrays). The authors also report a second example (DA466599) and suggest there is a need to clean up genomic databases but fear current tools will be inadequate to catch genes that have jumped the silicon barrier.

Anderson, M. T., and H. S. Seifert. 2011. Opportunity and means: horizontal gene transfer from the human host to a bacterial pathogen. mBio 2(1):e00005-11. doi:10.1128/mBio.00005-11

 Freeman, V.J. (1951). "Studies on the virulence of bacteriophage-infected strains of Corynebacterium diphtheriae". Journal of Bacteriology 61 (6): 675–688

Langdon, W. and Arno, M. (2011) More Mouldy Data: Virtual Infection of the Human Genome

Longo MS, O'Neill MJ, O'Neill RJ (2011) Abundant Human DNA Contamination Identified in Non-Primate Genome Databases. PLoS ONE 6(2): e16410. doi:10.1371/journal.pone.0016410

McClintock, B. (1929) A cytological and genetical study of triploid maize. Genetics, 14(2):180–222.

Thursday, June 23, 2011

Optimizing Biological Age

Lower Biological Age by Sleeping More

Sufficient sleep to optimize your biological aging process. We live in a world of sleep deprivation, a world where not sleeping enough is often seen as a badge of honor. But this lack of rest is causing the human body to break down and to have trouble functioning as well as it should with rest. Ideally, you should sleep approximately seven to eight hours each night to help lower your biological age. Of course, required sleep time for every person is different.

Eating More Vegetables Helps Improve Biological Aging

Biological aging is slowed with antioxidants. Vegetables are filled with antioxidants, vitamins, and minerals, all of which help your body repair itself and make itself stronger. When you make time to eat more vegetables each day, you are filling up your body with healthy nutrients, and not just empty calories. Eat five to ten servings of vegetables each day.

Sugar Increases Speed of Biological Age Process

Less sugar means aging slower. Sugar is something the body needs in order to function, but processed sugars are damaging to the organ systems. By reducing the amount of sugar in your diet, you can slow down the effects of aging, while also helping to control your hunger. Sugar causes glycation, which abnormally hardens your organs, including your skin.

Exercise More For Youth

Many benefits to exercise. Exercise not only helps your body pump more blood to the organs and to other parts of the body, but also releases factors into the body including gowth factors in the brain to induce brain growth. Increasing blood flow allows the body  to transport vital nutrients where they need to go. Just thirty minutes of exercise each and every day can help the body become more efficient while also helping you maintain a healthy weight.

Stop Smoking, Stop Aging

If you want to slow down your aging process, stop smoking. Smoking is one of the most damaging health habits a person can have. Smoking not only damages the lungs, but also breaks down the organs in the body, and makes skin appear older. Though it can be difficult to quit, there are many support options to help you manage nicotine cravings and withdrawal. Once you begin a smoke-free life, your body is already repairing itself of the damage and becoming younger as a result.

Eat Organic Nutrient Dense Foods And Supplement For Youthful Health

To properly fuel the body to remain youthful choose organic. Organic foods have more nutrients and fewer toxins than conventionally grown foods. One can be can overeat to the point of being obese and yet be malnourished because of poor food quality. Choose locally grown, wild foods, raised with biodynamic methods whenever possible. Supplementation with moderate doses of vitamins and minerals, and topicals for skin care is also recommended.

Choosing to change your life is simple, sticking with the plan can be more difficult. You may want to start off by only changing one habit at a time, allowing your body and your life a chance to adapt. By changing your health habits slowly, you have a greater change of success and of long term changes. Becoming biologically younger is a process that would require your attention and dedication until your choices become habit.

Sunday, June 19, 2011

S2RM Technology For Treating The Cornea Of Diabetics

In diabetic patients the stem cells in the cornea become less functional. Because the stem cells become dysfunctional, and, because the corneal tissue doesn't properly regenerate as occurs in healthy individuals, the diabetic cornea becomes prone to poor wound healing and other disorders that can cause pain and may lead to vision loss.

This condition is called diabetic keratopathy, and research has shown that diabetics' corneal stem cells become abnormal because their corneas may stop producing certain proteins that enable normal functioning of corneal stem cells. This is a problem of maintaining the stem cell niche of the cornea.

By employing a topical eye drop containing S2RM Technology, correction of the production of proteins in diabetics' corneas provides a treatment that will restore stem cell functions, spurring normal corneal cell turnover and keeping the tissue healthy and transparent. 

S2RM Technology is available in BioRegenerative Sciences' new product called I-Ease.

Saturday, June 18, 2011

Better Batteries: New Generation Lithium Ion Batteries

At the Equinox Summit of the Waterloo Global Science Initiative last week, future leaders were paired with scientists to imagine a new energy scenario for 2030, one that would cut greenhouse gas emissions, restrain a global society that relies on burning fossil fuels, and provide modern energy to the billions of people who are without such services today.

Better batteries, or "electricity in a bottle," would be the key factor in most of the proposed solutions, allowing electric energy to be efficiently stored and later distributed. Currently no battery provides near the energy density of liquid fuels; gasoline stores 12,000 watt-hours per kilogram compared to the best of today's lithium ion batteries at just 150 watt-hours per kilogram. Although batteries may never achieve the energy because of the nature of the underlying chemistry, better batteries can reduce the gap and allow batteries to be much more useful.

The technology underlying better batteries is complex. Lithium is explosive in water, but by encasing the lithium inside a special membrane, a lithium battery built by PolyPlus of Berkeley, CA reacts safely with the oxygen dissolved in the water and delivers as much as 1,300 watt-hours per kilogram of electricity. Of course, as I have discussed many times before, the new lithium ion battery technology derives from the “Triad,” a strong government supporting academic research at our great universities, who then work closely with private companies to translate the technology to the market.

PolyPlus is one of several better battery-makers that ARPA–e is funding, all attempting to improve on a standard lithium ion battery's roughly 400 watt-hours per kilogram; the reason why all-electric cars don't have the long-distance range of a traditional automobile. The program, called BEEST, for Batteries for Electrical Energy Storage in Transportation, has funded 10 projects, ranging from rechargeable batteries composed entirely of solid materials to high-energy density capacitors.

In the case of PolyPlus Battery Company, they have developed and patented protected lithium electrodes (PLEs) that are stable in a broad range of electrolytes, including aqueous and non-aqueous solvents. The invention of the PLE enables the development of a new class of ultra-high energy density batteries including lithium metal semi-fuel cells. PolyPlus encapsulates the lithium metal core using solid electrolyte membranes and a unique sealant. Important to their technology is that the solid electrolyte is highly conductive to lithium ions, but impervious to liquids and gases. This is the means for a lithium core that is electrochemically active but chemically isolated from the external electrolyte, allowing the construction of lithium-metal/aqueous batteries including lithium/air and lithium/water with unprecedented energy density.

Friday, June 10, 2011

Stem Cell Released Molecules From Multiple Stem Cell Types: S2RM Technology

The adult human uses stem cells to heal and regenerate tissue. A key means for the healing process elicited by stem cells is through the release of many molecules from different stem cell types into the surrounding, damaged tissue to orchestrate a healing response. The stem cell released molecules (SRM) are released from each type of stem cell, hence the terminology S2RM Technology, and work in concert to induce healing.

One means of delivering therapeutics to a patient is to adminster the adult stem cells directly to the patient in order for the stem cells to release their SRM into the damaged tissue. However, another means for delivering the SRM to the patients is to induce release of the SRM from the stem cells in a laboratory, and then to deliver the SRM directly to the patient without the stem cell.

Delivering SRM directly to the patient has advantges over delivering the stem cells to the patient, and then allowing the stem cells to release the SRM. By administering the SRM directly to the patient, an active, defined, and localized administration of the SRM to the damaged target tissue can be achieved. Further, the S2RM from combinations of stem cells can be combined in a therapeutically natural dose to induce optimal healing. For example, if damaged tissue precludes the stem cells from perfusing the damaged area of tissue, the molecules of the SRM can more easily penetrate and induce healing. Further, injected stem cells may not always remain in a viable state where the SRM is being released in therapeutic doses. However, when the SRM is directly injected or otherwise applied to the patient, a known dose to a defined site can better be achieved than when the stem cells themselves are injected or applied. This is a systems biology approach to developing therapeutics where multiple, integrated pathways are addressed by the therapeutic, instead of the traditional reductionist approach where one molecule addresses one pathway in therapeutic development.

The S2RM Technology, pioneered by BioRegenerative Sciences, Inc, has already achieved great success in treating a number of diseases and traumatized tissues, including dry eye and cataract, and future work will bring this technology to the clinic to treat many more indications.

Tuesday, June 7, 2011

Location And Function Of Stem Cells In The Skin And Scalp

Skin stem cells
Wear and tear is an everyday occurrence of life that your skin must cope with. For example, the skin is exposed to harsh chemicals like detergents, and to physical stresses such as friction with your clothes, environmental toxins, or exposure to sunlight. All of these factors damage the skin. The epidermis and skin need to be renewed constantly to maintain healthy skin. Furthermore, if you cut, burn, or damage your skin, the skin must be able to repair itself efficiently to keep performing its primary function of protecting your body from the outside world.
Skin stem cells make renewal of the skin possible. Stem cells are responsible for constant renewal (regeneration) of your skin, and for healing wounds. To date, scientists have identified three major types of skin stem cell in humans:
·         Epidermal stem cells are responsible for everyday regeneration of the different layers of the epidermis. These stem cells are found in the basal layer of the epidermis.
·         Hair follicle stem cells ensure constant renewal of the hair follicles. They can also regenerate the epidermis and sebaceous glands if these tissues are damaged. Hair follicle stem cells are found throughout the hair follicles. 
·         Mesenchymal stem cells are found in many parts of the body. In the skin, they are in the dermis and the hypodermis. Mesenchymal stem cells perform many regenerative functions in the skin and throughout the body.

BioRegenerative Sciences utilizes these different types of stem cells, and others, to produce our S2RM TechnologyTM to help heal the skin and scalp, and other parts of the body, and to regrow hair.